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  • Neurodegeneration

Publikationen

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(63) Shityakov S, Roewer N, Förster CY, Broscheit JA (2017) In silico investigation of propofol binding sites in human serum albumin using explicit and implicit solvation models. Computational Biology and Chemistry. 2017; Sep 70:191–197.

(62) Shityakov S, Roewer N, Förster CY, Broscheit JA (2017) In silico Modeling of Indigo and Tyrian Purple Single-Electron Nano-Transistors using Density Functional Theory Approach. Nanoscale Research Letter 2017 Dec;12(1):439.

(61) Neuhaus W, Krämer T, Neuhoff A, Thal S, Foerster CY (2017) Multifaceted mechanisms of WY-14643 to stabilize the blood-brain barrier during ischemia. Frontiers in Molecular Neuroscience. 2017; 10:149.

(60) Shityakov S, Broscheit JA, Roewer N, Förster CY (2017) In silico models for nanotoxicity evaluation and prediction at the blood-brain barrier interface. Computational Toxicology. 2017; May; 2:20-27.

(59) Shityakov S, Salmas R, Durdagi S, Roewer N, Förster CY, Broscheit J (2017) Solubility profiles, hydration and desolvation of curcumin complexed with γ-cyclodextrin and hydroxypropyl-γ-cyclodextrin. Journal of Molecular Structure. 1134 (2017) 91-98.

(58) Dilling C, Roewer N, Förster CY and Burek, M (2017) Multiple protocadherins are expressed in brain microvascular endothelial cells and might play a role in tight junction protein regulation. Journal of Cerebral Blood Flow and Metabolism. 2017; Jan 1:271678X16688706. doi: 10.1177/0271678X16688706

(57) Shityakov S, Salmas R, Durdagi S, Salvador E, Pápai K, Yañez-Gascón M, Perez-Sanchez H, Puskás I, Roewer N, Förster CY,  Broscheit JA,(2016) Characterization, In Vivo Evaluation and Molecular Modeling of Different Propofol-Cyclodextrin Complexes to Assess Their Drug Delivery Potential at The Blood-Brain Barrier Level. Journal of Chemical Information and Modeling. 2016; Oct24;56(10):1914-1922. 

(56) Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC (2016) Myeloid Cell-Derived VEGF Is Required To Maintain Brain Glucose Uptake And To Limit Cognitive Impairment In Obesity. Cell. 2016; May 5;165(4):882-95.

(55) Kumar N, Srivastava S, Burek M, Förster CY, Roy P (2016) Assessment of estradiol-induced gene regulation and proliferation in an immortalized mouse immature Sertoli cell line. Life Science. 2016; Mar 1;148:268-78.

(54) Shityakov S, Salmas R, Salvador E, Roewer N, Broscheit J and Förster CY (2016) Evaluation of the potential toxicity of unmodified and modified cyclodextrins on murine blood-brain barrier endothelial cells. Journal of Toxicological Sciences. 2016;41(2):175-84.

(53) Neuhaus W, Schlundt M, Fehrholz M, Ehrke A, Kunzmann S, Liebner S, Speer CP, Förster CY (2015) Multiple antenatal dexamethasone treatment alters brain vessel differentation in newborn mouse pups. Plos One. 2015, Aug 14;10(8):e0136221.

(52) Salvador E, Burek M, Förster CY (2015) Stretch and/or oxygen glucose deprivation (OGD) in an in vitro traumatic brain injury (TBI) model induces inflammatory cascade. Frontiers in Cellular Neuroscience. 2015; Aug 21;9:323.

(51) Shityakov S, Dandekar T and Förster C (2015) Gene expression profiles and protein-protein interaction network analysis in AIDS patients with HIV-associated encephalitis and dementia. HIV AIDS (Auckl). 2015; Nov 18;7:265-76.

(50) Shityakov S, Puskás I, Roewer N, Förster CY and Broscheit JA (2015) Optimized sevoflurane formulation with sulfobutylether-ß-cyclodextrin: technical note. Journal of Advanced Clinical Pharmacology. 2015; 2(1):12-14.

(49) Shityakov S, Puskás I, Papai K, Salvador E, Roewer N, Förster CY, Broscheit JA (2015) Sevoflurane-sulfobutylether-β-cyclodextrin complex: preparation, characterization, cellular toxicity, molecular modeling, and the blood-brain barrier transport studies. Molecules. 2015; Jun 3;20(6):10264-79.

(48) Shityakov S, Sohajda T, Puskás I, Roewer N, Förster CY, Broscheit JA (2014) Ionization states, cellular toxicity and molecular modelling studies of midazolam complexed with trimethyl-β-cyclodextrin. Molecules. 2014; Oct 21; 19(10):16861-76.

(47) Neuhaus W, Gaiser F, Mahringer A, Franz J,  Riethmüller C, Förster CY (2014) The pivotal role of astrocytes in an in-vitro stroke model of the blood-brain barrier. Frontiers in Cellular Neuroscience. 2014; 8 :352, doi: 10.3389/fncel.2014.00352.

(46) Shityakov S, Salvador E, Pastorin G, Förster CY (2015) Blood-brain barrier transport studies, aggregation, and molecular dynamics simulation of multiwalled carbon nanotube functionalized with fluorescein isothiocyanate. International Journal of Nanomedicine. 2015 ; 10: 1703-1713

(45) Burek M, Steinberg K, Förster CY (2014) Mechanisms of transcriptional activation of the mouse claudin-5 promoter by estrogen receptor alpha and beta. Molecular and Cellular Endocrinology. 2014; Jul 5;392(1-2):144-51.

(44) Burek M, Haghikia A, Gold R, Roewer N, Chan A and Förster CY (2014), Differential cytokine release from brain microvascular endothelial cells treated with dexamethasone and multiple sclerosis patient sera. Journal of Steroids & Hormonal Science. 2014; 5:128. doi: 10.4172/2157-7536.1000128

(43) Blecharz K G, Burek M, Bauersachs J, Thum T, Tsikas D, Widder J, Roewer N and Förster CY (2014) Inhibition of proteasome-mediated glucocorticoid receptor degradation restores nitric oxide bioavailability in myocardial endothelial cells. Biology of the Cell. 2014; Jul;106(7):219-35.

(42) Shityakov S, Förster CY, (2014) In silico predictive model to determine vector-mediated transport properties for the blood-brain barrier choline transporter. Advances and Applications in Bioinformatics and Chemistry. 2014; Sep 2; 7:23-36.

(41) Shityakov S, Förster CY, Rethwilm A, Dandekar T (2014) Evaluation and prediction of the HIV-1 central polypurine tract influence on foamy viral vectors to transduce dividing and growth-arrested cell. Scientific World Journal. 2014;487969. doi: 10.1155/2014/487969.

(40) Shityakov S, Broscheit JA, Roewer N, Foerster CY (2014) Three-dimensional quantitative structure-activity relationship and docking studies on a series of anthocyanin derivates as cytochrome P450 3A4 inhibitors. Advances and Applications in Bioinformatics and Chemistry. 2014; Mar 25;7:11-21.

(39) Shityakov S, Foerster CY (2013) Pharmacokinetic delivery and metabolizing rate of nicardipine incorporated in hydrophilic and hydrophobic cyclodextrins using two-compartment mathematical model. The Scientific World Journal. 2013; Dec 3;2013:131358.

(38) Shityakov S, Salvador E, Förster CY (2013) In silico, in vitro, and in vivo methods to analyse drug permeation across the blood-brain barrier: A critical review. OA Anaesthetics. 2013; Jul 01;1(2):13.

(37) Thal SC, Schaible EM, Neuhaus W, Scheffer D, Brandstetter M, Engelhard K, Wunder C, Förster CY (2013) Inhibition of proteasomal glucocorticoid receptor degradation restores dexamethasone-mediated stabilization of the blood-brain-barrier after traumatic brain injury. Critical Care Medicine. 2013; 41(5):1305-15.
Editorial: Kahles T, Vatter H, (2013) Glucocorticoids for the Prevention of Cerebral Edema in Traumatic Brain Injury: Mission (Im)possible?. Critical Care Medicine. 41(5): 1378-79.

(36) Salvador E, Neuhaus W, Förster CY (2013) Stretch in brain microvascular endothelial cells (cEND) as an in vitro traumatic brain injury model of the blood brain barrier. Journal of Visualized Experiments. 80:e50928. doi: 10.3791/50928

(35) Shityakov S and Förster CY (2013) Multidrug resistance protein P-gp interaction with nanoparticles (fullerenes and carbon nanotube) to assess their drug delivery potential: a theoretical molecular docking study. International Journal of Computational Biology and Drug Design. 6(4): 343-357.

(34) Prinz M; Parlar S; Bayraktar G; Alptüzün V; Erciyas E; Fallarero A; Karlsson D; Vuorela P; Burek M; Förster CY; Turunc E; Armagan G; Yalcin A; Holzgrabe U, (2013) 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors for AChE, BuChE and amyloid-β aggregation crossing the blood-brain-barrier. European Journal of Pharmaceutical Sciences. 49(4): 603-661.

(33) Shityakov S, Förster CY (2014) In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions. Advances and Applications in Bioinformatics and Chemistry. Volume 2014, 7:1-9.

(32) Shityakov S, Neuhaus W, Dandekar T and Förster CY (2012) Analyzingmolecular polar surface descriptors to predict blood-brain barrier permeation. International Journal of Computational Biology and Drug Design. 6(1-2):146-56.

(31) Neuhaus W, Samwer F, Kunzmann S, Muellenbach R, Wirth M, Speer C P, Roewer N, Förster CY (2012) Lung endothelial cells strengthen, but brain endothelial cellsweaken barrier properties of a human alveolar epithelium cell culture model. Differentiation. 84: 294–304.

(30) Burek M, Salvador E, Förster CY (2012) Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model. Journal of Visualized Experiments. (66), e4022 10.3791/4022, DOI: 10.3791/4022

(29) Shityakov S, Broscheit JA, Förster CY (2012) α-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studie. International Journal of Nanomedicine. 7: 3211–3219.

(28) Dakwar G, Kaplun V, Kojukarov L, Gorenbein P, Schumaher I, Förster CY, Stepensky D (2012) Toxicity assessment of extracts from infusion sets in cEND brain endothelial cells. International Journal of Pharmaceutics. 434: 20-27.

(27) Neuhaus W, Burek M, Djuzenova CS, Thal S, Koepsell H, Roewer N, and Förster CY (2012) Addition of NMDA-receptor antagonist MK801 during oxygen/glucose deprivation moderately attenuates the upregulation of glucose uptake after subsequent reoxygenation in brain endothelial cells. Neuroscience Letters. 506: 44-49.

(26) Neuhaus W, Schick MA, Bruno RR, Schneiker B, Foerster C, Roewer N, Wunder C (2012) The effects of colloid solutions on renal proximal tubulus cells in vitro. Anesthesia and Analgesia. 114(2): 371-374.

(25) Kleinschnitz C, Blecharz K, Kahles T, Schwarz T, Kraft P, Göbel K, Meuth SG, Burek M, Thum T, Stoll G and Förster CY (2011) Glucocorticoid insensitivity at the hypoxic blood-brain-barrier can reversed by inhibition of the proteasome. Stroke. 42(4):1081-1089.

(24) Bueter W, Saunders NR, Mallard C, Bauer H-C, Stolp HB, Kavelaars A, Dammann O, for the NEUROBID consortium* (2010) NEUROBID — an EU-funded project to study the developing brain barriers. International Journal of Developmental Neuroscience. 28(5):411-2, * Förster CY is member of the NEUROBID consortium.

(23) Muellenbach R M, Kredel M, Wilhelm J, Kuestermann J, Fink L, Siebenlist G, Klosterhalfen B, Foerster CY, Kranke P, Wunder C, Roewer N, Brederlau J (2010) High-frequency oscillation combined with arteriovenous extracorporeal lung assist reduces lung injury. Experimental Lung Research. 36(3): 148-58.

(22) Blecharz K, Chan A, Haghikia A, Kruse N, Drenckhahn D, Gold R, Roewer N, Foerster CY (2010) Glucocorticoid effects on endothelial barrier function in the murine brain endothelial cell line cEND incubated with sera from patients with multiple sclerosis. Multiple Sclerosis Journal. 16(3): 293-302.

(21) Lecht S, Förster CY, Arien-Zakay H, Marcinkiewicz C, Lazarovici Ph, Lelkes PI (2010) Cardiac microvascular endothelial cells express and release nerve growth factor but not fibroblast growth factor-2. In Vitro Cellular & Developmental Biology – Animal. 46(5):469-76.

(20) Burek M, Arias-Loza P A, Pelzer T, Roewer N, Förster CY (2009) Claudin-5 as a novel estrogen target in vascular endothelium. Arteriosclerosis, Thrombosis, and Vascular Biology. 30(2):298-304.

(19) Burek M, Förster C (2009) Cloning and characterisation of the murine claudin-5 gene promoter. Molecular and Cellular Endocrinology. 298 (1-2):19-24.

(18) Harke N, Leers J, Kietz S, Drenckhahn D, Förster CY (2008) Glucocorticoids regulate the human occludin gene through a single imperfect palindromic glucocorticoid response element. Molecular and Cellular Endocrinology. 295:39-47.

(17) Förster CY, Burek M, Romero I A, Weksler B, Couraud P O, Drenckhahn D (2008) Differential effects of hydrocortisone and TNFα on tight junction proteins in an in vitro model of the human blood-brain barrier. The Journal of Physiology. 586.7:1937-1949.

(16) Blecharz K, Drenckhahn D, Förster CY (2008) Glucocorticoids increase VE-cadherin expression and cause cytoskeletal re-arrangements in murine brain endothelial cEND cells. Journal of Cerebral Blood Flow & Metabolism. 28: 1139-49.

(15) Förster CY, Kahles T, Kietz S, Drenckhahn D (2007) Dexamethasone induces the expression of metalloproteinase inhibitor TIMP-1 in the murine cerebral vascular endothelial cell line cEND. The Journal of Physiology. 580.3: 937-49.

(14) Silwedel C, Förster CY (2006) Differential susceptibility of cerebral and cerebellar endothelial cell lines to blood-brain barrier breakdown in response to inflammatory stimuli. Journal of Neuroimmunology. 179(1-2):37-45.

(13) Förster CY, Waschke J, Burek M, Leers J, Drenckhahn D (2006) Glucocorticoid effects on microvascular endothelial barrier permeability are brain specific. The Journal of Physiology. 573.2: 413-25.

(12) Helguero L A, Hedengran-Faulds M, Förster CY, Gustafsson J-Å, Haldosén L-A (2006) Dax-1 is regulated by EGF throughout mammary epithelial cell differentiation. Endocrinology 147(7):3249-59.

(11) Förster CY, Silwedel C, Golenhofen N, Kietz S, Mankertz J, Drenckhahn D (2005) Occludin as direct target for glucocorticoid-induced improvement of blood-brain barrier properties in a murine in vitro system. The Journal of Physiology. 565.2:475-86.

(10) Förster CY, Kietz S, Hultenby K, Warner M, Gustafsson J.-A. (2004) Characterization of the ERbeta-/- mouse heart. Proceedings of the National Academy of Sciences USA. 101(39):14234-9.

(9) Genner M, Förster CY, and Findlay JBC (2003) Developing a scientific career: Issues concerning the present state of Marie Curie Fellowships – Perceived Futures. Proceedings of the EC Marie Curie Fellowships.

(8) Förster CY, Makelä S, Wärri A, Becker D, Hultenby K, Warner M, Gustafsson J-A (2002) Involvement of estrogen receptor  in terminal differentiation of mammary epithelium. Proceedings of the National Academy of Sciences USA. 99:15578-15583.

(7) Förster CY, Revuelta J, Krämer R (2001) Carrier-mediated transport of riboflavin in Ashbya gossypii. Applied Microbiology and Biotechnology. 55:85-89.

(6) Förster CY, Kane P M (2000) Cytosolic Ca2+ homeostasis is a constitutive function of the V-ATPase in Saccharomyces cerevisiae. Journal of Biological Chemistry. 275: 38245-38253.

(5) Förster CY (1999) Biochemische und molekularbiologische Charakterisierung des Riboflavintransports in Ashbya gossypii. Dissertation, Universität Hannover JUEL-3626.

(4) Förster CY, Ruffert S, Santos M A, Krämer, Revuelta J L (1999) Physiological consequences of disruption of the VMA1 gene in the riboflavin overproducer Ashbya gossypii. Journal of Biological Chemistry. 274: 9442 – 9448.

(3) Förster CY, Marienfeld S, Wilhelm R, Krämer R (1998) Organelle purification and selective permeabilization of the plasma membrane: two different approaches to study vacuoles of the filamentous fungus Ashbya gossypii. FEMS Microbiology Letters. 167: 209-214.

(2) Förster CY, Marienfeld S, Wendisch V F, Krämer R (1998) Adaptation of the filamentous fungus Ashbya gossypii to hyperosmotic stress: different osmoresponse to NaCl and mannitol stress. Applied Microbiology and Biotechnology. 50: 219-226.

(1) Förster CY, Marienfeld S,Wilhelm R, Krämer R (1997) Monitoring riboflavin fluxes across the vacuolar membrane of A. gossypii by selective permeabilization of the plasma membrane. Fak. Landbouww. Gent. 62: 245-11248 (ungelistete Zeitschrift).

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Übersichtskapitel

(9) Shityakov S, Broscheit JA, Roewer N, Förster CY (2017) In silico models for nanotoxicity evaluation and prediction at the blood-brain barrier level: A mini-review Journal of Computational Toxicology. 2(2017):20-27.

(8) Salvador E, Burek M, Förster CY (2016) Tight Junctions and the Tumor Microenvironment. Current Pathobiology Reports. 4: 135. Invited review.

(7) Helms HC, Abbott NJ, Burek M, Ceccelli R, Couraud PO, Deli M, Förster CY, Galla HJ, Romero IA, Shusta EV, Stebbins M, Vandenhaute E, Weksler B, Brodin B (2016) In vitro models of the blood-brain barrier; An overview of commonly used brain endothelial cell culture models and guidelines for their use. Journal of Cerebral Blood Flow and Metabolism. Vol. 36(5) 862–890. Invited review.

(6) Salvador E, Shityakov S, Förster CY (2014) Glucocorticoids and EC barrier function, Special Issue of Cell and Tissue Research. 355 (3): 597-605.

(5) Bruhn C, Manninga H and Förster CY (2012) Überwindung der Blut-Hirn-Schranke – welche Methoden haben Zukunft, Med. Wochenschrift. 137 (21): 1086-1087.

(4) Burek M, Förster C (2010) Glucocorticoid-mediated Regulation of Tight Junctions in Brain Vascular Endothelium. Brain Research Journal. 3 (1):37-52.

(3) Förster CY (2008) Tight junctions and the modulation of barrier function in disease. Eingeladener Übersichtsartikel zum 50jährigen Jubiläum: Histochemistry and Cell Biology. 130(1):55-70 Epub 2008 Apr 16.

(2) Förster CY, Kietz S (2006) Rolle von Östrogenrezeptor beta in der Vermittlung zellulärer Differenzierungsprozesse. Eingeladener Übersichtsartikel in Rubrik „Schlaglicht“: Biospektrum. 2:162 - 164 Biospektrum Akad. Verlag. Invited review.

(1) Förster CY (2005) Glucocorticoid regulation of blood brain barrier permeability.
Physiology News. 61:34-35. Invited review.

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Buchkapitel

(8) Salvador E, Burek M, Förster CY “Blood-Brain Barrier – Methods and Protocols“ Editor:  Barichello T, Springer Nature, 2017  in Vorbereitung

(7) Salvador E, Burek M, Förster CY, "An In Vitro Model of Traumatic Brain Injury". In: "Traumatic and Ischemic Injuries; Methods in Molecular Biology" Eds.: Tharakan B and Walker JM, Springer, 2016 in Vorbereitung

(6) Burek M, Salvador E, Förster CY, “Development of mouse in vitro blood-brain barrier models”. In: “Stem Cell Technologies in Neuroscience“. Eds.: E. Snyderk and A. K. Srivastava. Springer Neuromethods, NY, 2017, chapter 9, ISBN: 978-1-4939-7022-3, p.135-143.

(5) Burek M, Salvador E and Förster CY, “Cell-based in vitro blood-brain barrier models for drug permeability studies.” In: "Concepts and models for drug permeability studies - Cell and tissue-based in vitro culture models". Editor: B. Sarmento. Elsevier, 2015, 1st Edition, ISBN: 9780081000946, p.346-356.

(4) Salvador E and Forster CY, “The causal contribution of selective blood-brain barrier to glucose transport in brain edema and function deterioration after ischemia and brain injury.”  In:  Adaptation Biology and Medicine: New Developments.  Eds. L.M. Popescu, A.R. Hargens and P.K. Singal.  Narosa Publishing House, New Delhi, 2013, Vol. 7, ISBN: 978-81-8487-274-9, pp. 213 – 220.

(3) Neuhaus W, Burek M, Wunder  C and Förster  CY, „Novel strategies to restore Blood-Brain Barrier integrity after brain injury”, in “The Blood-Brain Barrier: New Research”, Publisher: Nova Science,1st Edition, Hauppauge NY, 2012 1st quarter, chapter 5, ISBN 978-1-62100-766-1, pp. 148-171.

(2) Burek M, Förster CY, “Glucocorticoid-mediated Regulation of Tight Junctions in Brain Vascular Endothelium, in “Glucocorticoids: Effects, Action Mechanisms, and Therapeutic Uses”, Publisher: Nova Sience, 1st Edition, Hauppauge NY, 2010 4th quarter, chapter 9, ISBN 978-1-61728-758-9; pp. 187-202.

(1) Förster CY, Kietz S and Gustafsson J.-A, “Estrogen receptor b involvement in cell adhesion signaling and gap junctional communication in differentiateing mammary gland” in “Parker, M.G. and Valverde, M.A. (Eds.), Genomic vs. Non-Genomic Steroid Actions: Encountered or Unified Views”, Publisher: Serie Universitaria, 2002,Vol. 131, Madrid, pp. 63-65.

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Konferenzschriften

(7) Shityakov S, Roewer N, Broscheit JA, Förster CY (2017) In silico investigation of different propofol binding sites in human serum albumin using linear interaction energy method. Journal of Drug Design, Development and Therapy. molecules-148731. in Druck.

(6) Oerter S, … Grieß-Porsch S, Förster CY, Monoranu C, Koepsell H, Bohnert M (2016) Die Expression von Natrium-Glukose-Transportern im menschlichen Gehirn post mortem. Rechtsmedizin. 26(4):365.

(5) Shityakov S, Förster CY (2015) Systems biology approaches for discovering new glucocorticoid-mediated pathways at the blood-brain barrier. Journal of Vascular Research. 52(suppl 1) p. 33.

(4) Shityakov S, Förster CY (2014) Molecular dynamics simulation of propofol bound to human serum albumin using linear interaction energy method. Medicinal chemistry. 2014, 4:12.

(3) Burek M, Blecharz KG, Bauersachs J, Thum T, Tsikas D, Widder J, Roewer N, Förster CY (2012) Restoration of endothelial nitric oxide bioavailability in myocardial endothelial cells treated with dexamethasone. Vascular Pharmacology. 56(5/6):351.

(2) Kleinschnitz C, Blecharz K, Kahles T, Schwarz T, Kraft P, Göbel K, Meuth SG, Burek M, Thal S, Scheffer D, Thum T, Stoll G, and Förster CY (2012) Novel steroid-based strategy to restore blood brain barrier integrity after ischemic brain injury. European Journal of Anaesthesiology. 29 (A06): 49.

(1) Kleinschnitz C, Blecharz K, Kahles T, Schwarz T, Kraft P, Göbel K, Meuth SG, Burek M, Thal S, Scheffer D, Thum T, Stoll G, and Förster CY (2012) Glucocorticoid signalling and resistance at the blood-brain barrier in central nervous system disorders. Conference Paper in Vascular Pharmacology. 56(5-6):355.

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Erfindungsmeldungen und Patente

(10) Förster CY (2016) Generierung einer murinen immortalisierten Hirnendothelzelllinie cENDsglt1-/- defizient am NA+-abhängigen Glucose-Transporter SGLT-1, Erfindungsmeldung Universität Würzburg. EP-Patent pending.

(9) Förster CY (2015) Auslizensierung der immortalisierten zerebralen Hirnendothelzellinien cEND und cerebEND an die Firma Applied Biological Materials Inc. (www.abmGood.com)

(8) Förster CY (2012) miR-CF1 als Target zur Minderung von Blut-Hirnschranken-Störungen, Ödembildung und Symptomen der Hirnfunktionsstörung nach ischämischem Schlaganfall, Erfindungsmeldung, Baypat prüft Patentierbarkeit.

(7) Förster CY (2011) Etablierung eines alveolaren Lungenepithelzellkulturmodells zum Studium der molekularen Effekte von Lungenschädigungen, Erfindungsmeldung, Baypat prüft Patentierbarkeit.

(6) Förster CY (2011) SGLT2 als Ziel für die Therapie von Hirn-Ödemen und Anwendung spezifischer SGLT2 Agonisten Erfindungsmeldung Universität Würzburg. EP-Patent pending.

(5) Förster CY (2009) Neue Steroid-basierte Kombinationstherapie zur Behandlung von Blut-Hirn-Schrankenstörungen in GC-refraktären Erkrankungen. WO-Patent Universität Würzburg. WO2011/039282A1.

(4) Förster CY (2009) Neue Steroid-basierte Kombinationstherapie zur Behandlung von Blut-Hirn-Schrankenstörungen in GC-refraktären Erkrankungen. EP-Patent Universität Würzburg. EP 090123308.

(3) Harke N, Leers J, Kietz S, Drenckhahn D, Förster CY (2007) Identification of a distal glucocorticoid responsive element in the occludin gene coding region. Erfindungsmeldung Universität Würzburg.

(2) Förster CY, Santos M A, Zelder O, Revuelta J L, Krämer R (1998) Organismen zur extrazellulären Herstellung von Riboflavin. DE-Patent 19839567.1

(1) Förster CY, Santos M A, Zelder O, Revuelta J L, Krämer R (1998) ORGANISMS FOR THE EXTRACELLULAR PRODUCTION OF RIBOFLAVIN, WO-Patent WO/2000/012,748

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Arbeiten eingereicht und in Vorbereitung

(7) Oerter S, Wunder C, Bohnert M, Foerster CY (2017) A new way of brain glucose transport - Evidence of SGLT1 in capillaries of the human brain. Nature Cell Biology. eingereicht

(6) Shityakov S, Broscheit JA, Roewer N, Förster CY (2017) In silico models for nanotoxicity evaluation and prediction at the blood-brain barrier level: A mini-review (TNAN-2017-0045). Nanotoxicology. eingereicht

(5) Burek, M, Koch, A, Förster CY (2016) Evaluation of the murine cEND cell line as a model for Aß clearance by the blood-brain barrier. in Vorbereitung

(4) Schaible E, Schwarzmaier S, Yang D, Neuhaus W, Burek M, Förster CY, Trabold R, Plesnila N, Engelhard K, Schäfer M and Thal SC (2016) Inhibition of plasminogen activator inhibitor-1 (PAI-1) attenuates posttraumatic brain damage progression by  enhanced fibrinolysis. eingereicht

(3) Kaiser M, Bulla S, Lankamp F, Ketelhut S, Kemper B, Burek M, Förster CY, Christian G, Goycoolea  FM (2016) The influence of capsaicin on the integrity of endothelial cell monolayers. eingereicht

(2) Neuhaus W, Scheffer D, Roewer N, Förster CY, Effects of combination therapy with dexamethasone and bortezomib in a human blood-brain barrier in vitro stroke model. in Vorbereitung

(1) Schaible E, Petkovic I, Burek M, Pieter D, Timaru-Kast R, Förster CY, Trabold R, Schäfer MK, Engelhard K, Thal SC (2017) Plasminogen activator inhibitor-1 (PAI-1)enhances secondary brain damage by impairing fibrinolysis after traumatic brain injury. Scientific Reports. Reference number: SREP-17-29619 eingereicht

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Eingeladene Vorträge

(57) Förster C “Exploring New Innovations and Frontiers in Heart Care”, 21st International Conference on Clinical and Experimental Cardiology, November 06-07, 2017, Las Vegas, Nevada, USA

(56) Förster C “Exploring New Innovations and Frontiers in Heart Care”, National Congress of Cardiology, May 31-??, 2018, Mendoza, Argentinien

(55) Förster C und Burek M, „ MicroRNA based therapy in disease models of heart failure and stroke“, World Heart Congress, May 22-24, 2017, Osaka, Japan

(54) Oerter S, Grieß-Porsch S, Monoranu C, Förster CY, Koepsell H, Bohnert M „Nachweis und Lokalisierung der Expression von Natrium-Glukosetransportern im menschlichen Gehirn post mortem.“ 95. Jahrestagung der Deutschen Gesellschaft für Rechtsmedizin (DGRM), August 30 – September 3, 2016, Heidelberg, Germany

(53) Förster C, “Evaluation of the potential toxicity of unmodified and modified cyclodextrins on murine blood-brain barrier endothelial cells.” EMN Meeting on Structural Nanomaterials-2016, November, 14-17th, 2016 at Dubai, United Arab Emirates

(52) Shityakov, S. and Förster, C, "In silico predictive model to determine vector-mediated transport properties for the blood-brain barrier choline transporter ", Fourth International Conference on Advances in Bio-Informatics and Environmental Engineering - ICABEE 2016, August 18-19, 2016, Rome, Italy

(51) Förster C, “Advancements and Challenges in Neurosciences & Neurological Disorders”, 6th World Neurological Conference during June 8-10, 2016, at Dallas, USA

(50) Förster C, “Sevoflurane-Sulfobutylether-β-Cyclodextrin Complex: Preparation, Characterization, Cellular Toxicity, Molecular Modeling and Blood-Brain Barrier Transport Studies”, International Conference on Pharmaceutical Chemistry-2016,
September 08-10, 2016, Frankfurt, Germany

(49) Förster C, “Stretch and/or oxygen glucose deprivation (OGD) in an in vitro traumatic brain injury (TBI) model induces calcium alteration and inflammatory cascade”, 7th Global Neurologists Annual Meeting on Neurology and Neurosurgery on August 22-24, 2016, Vienna, Austria

(48) Förster C, “Inhibition of proteasome-mediated glucocorticoid receptor degradation restores nitric oxide bioavailability in myocardial endothelial cells in vitro”, Biotechnology World Convention 2016, August 15-17, 2016, Sao Paulo, Brazil

(47) Shityakov, S. and Förster, C, “Characterization and in vivo evaluation of different propofol-cyclodextrin complexes to assess their drug delivery potential at blood-brain barrier level”, 18th Barrier- and Transporter-Meeting, May 02-04, 2016, Karlsruhe, Germany

(46) Förster C and Salvador E,  “Stretch and/or oxygen glucose deprivation (OGD) in an in vitro traumatic brain injury (TBI) model induces calcium alteration and inflammatory cascade”, 4th Global Experts Meeting on Neuropharmacology scheduled on September 15-17, 2016 at San Antonio, USA

(45) Förster C and Burek M, “Mechanisms of transcriptional activation of the mouse claudin-5 promoter by estrogen receptor alpha and beta”, 3rd International Conference on Endocrinology
Dates:  November 02-04, 2015
Atlanta, USA

(44) Förster C and Salvador E. “Anti-diabetic Effects of Breast-feeding at the Blood Brain Barrier (BBB)”,
Diabetes: New Insights into Molecular Mechanisms and Therapeutic Strategies October 25—29, 2015, Westin Miyako Kyoto, Kyoto, Japan

(43)  Förster C and Salvador E. “Anti-diabetic Effects of Breast-feeding at the Blood Brain Barrier (BBB)”,
9th Intl Congress on Vascular dementia: October 16—19, 2015, Ljubljana, Slowenia

(42) Förster C, “Glucocorticoid regulation perinatal medicine.”
Global Summit on Steroids July 13-15, 2015 at Baltimore, USA

(41) Shityakov, S. and Förster, C. „In silico predictive model to determine vector-mediated transport properties for the blood–brain barrier choline transporter„ Bloodsurf Workshop, 03.- 07. November 2014, Fréjus, France 

(40) Förster C, “Rolle der Blut-Hirn-Schranke in der neurobiologischen Physiologie und Pathologie”. Entwicklungsbiologisches Seminar, Technische Universität Braunschweig, 02.-03.06.2014

(39) Förster C, “Targeting the blood brain barrier in neurological disorders”, Pharmacological colloquium, University of Linköping, Sweden, 21.-22.01.2014

(38) Förster C, „Causal contribution of BBB glucose transport to brain edema formation after brain injury“, Barriers of the CNS conference 2013, Lanzarote, Spain, 10.02.2013 – 13.02.2013

(37) Förster C, „Investigation of the causal contribution of selective blood-brain barrier glucose transport processes to brain edema formation and functional deterioration after experimental focal brain ischemia and traumatic brain injury“, Jahrestagung der Gesellschaft für Mikrozirkulation und Vaskuläre Biiologie, Mannheim, Germany, 27.09.2012 - 29.09.2012

(36) Förster C, “Effects of synthetic glucocorticoids on fetal and newborn BBB maturation: implications in adverse health consequences”, 15th International Symposium Signal Transduction in the Blood-Brain-Barriers, Potsdam, Germany, 13.09.2012 – 16.09.2012

(35) Förster C, “Role of the blood brain barrier in secondary brain injury development - folly adaptations for survival?”, The 10th WORLD  CONGRESS of the International Society For ADAPTIVE  MEDICINE, Bucharest, Romania, 07.06.2012 – 10.06.2012

(34) Förster C, „Glucocorticoid signalling and resistance at the blood-brain barrier in central nervous system disorders”, 14th Symposium on Signal Transduction in the Blood Brain Barriers 2011, Istanbul, Turkey, 07.09.2011 – 09.09.2011

(33) Förster C, “Glukokortikoid-Effekte und -Resistenzen an der Blut-Hirn Schranke in Erkrankungen des Zentralen Nervensystems“, 13. Bad Herrenalber Transporter-Tage, Bad Herrenalb, 30.05.2011 – 01.06.2011,

(32) Förster C, “Glucocorticoid signalling and resistance at the BBB in central nervous system disorders “, Gordon Research Conference, Barriers of the CNS, , New Lodon, New Hampshire, USA 20.06.2010 – 25.06.2010

(31) Förster C, “Going nuclear – novel targets for molecular glucocorticoid action at the blood brain barrier”, Universität Würzburg, Klinik und Poliklinik für Anästhesiologie, 09.12.2008,

(30) Förster C, “Going nuclear – novel targets for molecular glucocorticoid action at the blood brain barrier”, Universität Erlangen-Nurnberg, Institut für Anatomie,  26.07.2008

(29) Förster C, “Molecular mechanisms of glucocorticoid-mediated regulation of BBB permeabilit.”, Biochem. Kolloquium der WWU Münster, Institut für Biochemie, WWU Münster, 29.05.2008

(28) Förster C, „Molekulare Mechanismen der Glucocorticoid-vermittelten Regulation der Blut-Hirn-Schranke“, 21. Blut-Hirn-Schranke-Expertentreffen, Universität Heidelberg, 19.05.2008

(27) Förster C, „Neuroinflammation – vom Verständnis der Pathogenese zur Entwicklung neuer  Glucococorticoid-basierender Behandlungskonzepte“, Exzellenzcluster Entzündung an Grenzflächen, Universität zu Lübeck, 15.04.2008

(26) Förster C, „Molekulare Mechanismen der Glucocorticoid-vermittelten Regulation der Permeabilität der Blut-Hirn-Schranke“, Joint-Symposium SFB 688/SFB612 Düsseldorf, 2008

(25) Förster C, „Molekulare Mechanismen der Glucocorticoid-vermittelten Regulation der Permeabilität der Blut-Hirn-Schranke“, Universität Erlangen-Nurnberg, 2007

(24) Förster C, „Molekulare Mechanismen der Glucocorticoid-vermittelten Regulation der Permeabilität der Blut-Hirn-Schranke“, 24. Arbeitstagung der Anatomischen Gesellschaft, Würzburg, 2007

(23) Förster C, „Glukocortikoid-Signaltransduktion als molekularer Mechanismus der Permeabilitätsregulation in Endothelzellen der Blut-Hirn-Schranke.“ Arbeitstagung der Anatomischen Gesellschaft, Würzburg, 16. – 19.09.2004.

(22) Förster C, Julius-Maximilians-Universität Würzburg, Institute Anatomie & Zellbiologie, interdisciplinary research center IZKF, 2003

(21) Förster C, Ruhr- Universität Bochum, Institute Biochemistry, 2003

(20) Förster C, Universität Stuttgart-Hohenheim, Institut für Immunologie & Zellbiologie, collaborative research center/ SFB 495, 2003

(19) Förster C, Universität Osnabrück, Institut für Mikrobiologie, collaborative research center/ SFB 431, 2003

(18) Förster C, Martin-Luther-Universität Halle-Wittenberg, Institut für Pharmakologie und Toxikologie, 2002

(17) Förster C, “Developing a Scientific Carreer.” Marie Curie Fellowships European Scientific Workshop. Participation invited as Rapporteur for EC Marie Curie Annals, Donostia-San Sebastián, 28.11.2002 – 30.11.2002

(16) Förster C, Julius-Maximilians-Universität Würzburg, Institut für Pathologie, interdisciplinary research center IZKF, 2002

(15) Förster C, Albert-Ludwigs-Universität Freiburg i.Br., Institut für Biochemie, Med. Fak., 2002

(14) Förster C, “Nuclear receptors”, Huddinge, Sweden, 25.08.2002 -28.08.2002

(13) Förster C, Universität Münster, Institut für Physiologie, 2002

(12) Förster C, Forschungszentrum Jülich, Institut Schichten und Grenzflächen, 2002

(11) Förster C, Friedrich-Schiller-Universität Jena, Institut für Neurowissenschaft, interdisciplinary research center IZKF, 2002

(10) Förster C, Philipps-Universität Marburg/ Lahn, Institut Physiologie, 2002

(9) Förster C, “EMBO course: imaging systems in living cells”, Institute of Ophthalmology, University College London, London, UK, 18.06.2001 – 30.06.2001

(8) Förster C, Dept. Medical Nutrition, Karolinska Institutet, Stockholm, Sweden, 2000

(7) Förster C, State University of NY, Syracuse, NY, USA, 1999

(6) Förster C, Dept. Biochem. and Molec. Biol., SUNY Health Science Center at Syracuse, Syracuse, NY, USA, 1999

(5) Förster C, VAAM/ GBM research young investigator award for Biochemistry and Microbiology, Georg-August- Universität Göttingen, 1999

(4) Förster C, Universidad de Salamanca, Dept. Microbiologia y Genetica, Spanien, Oktober 1997

(3) Förster C, BASF AG, Division „Mikrobielle Synthesen, Ludwigshafen, 1998

(2) Förster C, BASF AG, Division „Mikrobielle Synthesen, Ludwigshafen, 1997

(1) Förster C, BASF AG, Division „Mikrobielle Synthesen, Ludwigshafen, 1996

Nach oben

Posterpräsentation

(72) Oerter S, Morschek L, Monoranu C, Förster CY, Bohnert M (2016) Nachweis des Glukosesensors SGLT3 im postmortalen menschlichen Gewebe. 95. Jahrestagung der Deutschen Gesellschaft für Rechtsmedizin (DGRM), August 30 – September 3, 2016, Heidelberg, Germany

(71) Burek M, Salvador E, Förster CY (2015) Stretch and/or oxygen glucose deprivation in an in vitro traumatic brain injury model induces calcium alteration and inflammatory cascade. Barcelona BioMed Conference Blood Brain Barrier, Barcelona, Spain, 2-4.11.2015

(70) Neuhaus W, Gaiser F, Kraemer T, Membier S, Mayrhofer J, Docagne F, Macrez R, Vivien D, Franz J, Riethmüller C, Mahringer A, Subileau EA, Chesneh C, Thald S, Förster CY (2015) An in-vitro blood-brain barrier model for ischemia: Validation and Applicability. 2nd Barriers of the CNS Conference, Parador Oropesa, Spain, 27-30.9.2015

(69) Burek M, König A, Fiedler J, Thum T and Förster CY (2015) Hypoxia-induced microRNA-132/212 alter blood-brain barrier integrity through inhibition of tight junction-associated proteins in mouse and human brain microvascular endothelial cells, The 11th International Conference on Cerebral Vascular Biology and 18th International Symposium on Signal Transduction at the Blood-Brain and Blood-Retina Barriers, Paris, France, 5-9.7.2015

(68) Salvador E, Burek M, Förster CY “Calcium levels and inflammatory response are altered by stretch and/or oxygen-glucose deprivation (OGD) in an in vitro model of the blood brain barrier (BBB)” 17. Herrenalber Transporter-Tage, Bad Herrenalb, 11-13.5.2015                               

(67) Burek M, König A, Fiedler J, Thum T and Förster CY “Hypoxia-induced microRNA-132/212 alter blood-brain barrier integrity through inhibition of tight junction-associated proteins in mouse brain microvascular endothelial cells” 17th Symposium on Signal Transduction in the Blood Brain Barriers, Dublin, Irland, 11.09.2014-13.09.2014

(66) Neuhaus W, Mencl S, Kleinschnitz C, Foerster CY "Antenatal Inflammation Leads to Attenuated Blood-Brain Barrier Permeability after Stroke in Young Adult Mice", abstract and poster at the 16th International Symposium on Signal Transduction at the Blood-Brain and Blood-Retina Barriers, Dublin, Ireland, 11th-13th September 2014.

(65) Shytiakov S, Burek M, Förster CY (2014) Cellular toxicity and transport studies across the bloodbrain barrier of general anesthetics formulated with β-cyclodextrin derivatives to improve controlled drug delivery. MedTechPharma 2014; Juli 2-3, Nürnberg

(64) Burek M, Mann J, Roewer N, Förster CY “Anti-inflammatory and barrier stabilizing effects of anthocyanidins on the blood-brain barrier in vitro”. 16. Herrenalber Transporter-Tage, Bad Herrenalb, 26-28.5.2014

(63) Burek M, Fiedler J, Thum T and Förster CY “Evaluation of hypoxia-induced microRNA-132/212 targets in brain microvascular endothelial cells”, Blood Brain Barrier Meeting, Oregon Health & Science University, Sunriver, Oregon, USA, 20.03.2014 – 22.03.2014

(62) Neuhaus, W, Neuhoff, A, Gaiser, F, Foerster, CY "Novel therapeutical in-vitro approaches for stroke treatment: The role of the tPA/PAI-1 axis at the blood-brain barrier", abstract and poster at the 16th International Symposium on Signal Transduction in the Blood-Brain Barriers, Sümeg, Hungary, 12th-14th September 2013.

(61) Burek M, Kneitz S, Thal SC, Thum T, Förster CY “Effects of hypoxia on microRNA expression in murine brain microvascular endothelial cells”, 18th International Conference on Cerebral Vascular Biology, Montréal, Canada, 18.06.2013 – 21.06.2013

(60) Salvador E, Neuhaus W, Koepsell H, Thal S and Förster CY, “Causal contribution of BBB glucose transport to brain edema formation after brain injury”, 18th International Conference on Cerebral Vascular Biology, Montréal, Canada, 18.06.2013 – 21.06.2013

(59) Salvador E, Förster CY, “Sodium-dependent glucose transporter SGLT1 expression in the blood brain barrier as a result of injury using an in vitro traumatic brain injury model”, 15. Bad Herrenalber Transporter-Tage 2013, Bad Herrenalb, Germany, 13.05.2013 – 16.05.2013

(58) Neuhaus W, Förster CY, “NMDAR subunit NR1 is essential for blood-brain barrier damage and cell motility in an in vitro mouse stroke model”, 15. Bad Herrenalber Transporter-Tage 2013, Bad Herrenalb, Germany, 13.05.2013 – 16.05.2013

(57) Burek M, Kaiser T, Roewer N, Förster CY, “Role of estrogen receptor beta over-expression in transmigration of breast cancer cells though the blood-brain barrier in vitro”, Beating the Blood-Brain and other Blood-Barriers, Lisbon, Portugal, 06.02.2013 – 09.02.2013

(56) Neuhaus W, Burek M, Förster CY, “PPARα agonists stabilize the blood-brain barrier after in-vitro stroke by inhibition of MMP and proteasome activity”, Beating the Blood-Brain and other Blood-Barriers, Lisbon, Portugal, 06.02.2013 – 09.02.2013

(55) Neuhaus W, Burek M, Roewer N, Förster CY, “Inhibition of OGD induced and astrocyte enhanced blood-brain barrier breakdown by specific receptor modulators”, 15th International Symposium Signal Transduction in the Blood-Brain-Barriers, Potsdam, Germany, 13.09.2012 – 16.09.2012

(54) Shityakov S, Neuhaus W, Förster C, „Analyzing molecular polar surface descriptors to predict blood-brain barrier perYmeation.“, Biomedica Online Kongress 2012

(53) Shityakov S, Broscheit JA, Förster CY, “α-Cyclodextrin dimer  complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studies”, 3rd International Conference "Strategies in Tissue Engineering", Würzburg, Germany, 23.05.2012 – 25.05.2012

(52) Burek M, Förster CY, “Generation of an immortalized murine brain microvascular endothelial cell line as an in vitro blood brain barrier model”, 3rd International Conference "Strategies in Tissue Engineering", Würzburg, Germany, 23.05.2012 – 25.05.2012

(51) Neuhaus W, Förster CY, „The Role of Astrocytes in a Mouse Blood-Brain-Barrier in vitro Model of oxygen/glucose deprivation“,3rd International Conference "Strategies in Tissue Engineering", Würzburg, Germany, 23.05.2012 – 25.05.2012

(50) Neuhaus W., Förster CY., “Interplay of astrocytes and receptor ligands in a mouse blood-brain barrier in vitro model of oxygen/glucose deprivation” 14. Bad Herrenalber Transporter-Tage 2012, Bad Herrenalb, Germany, 14.05.2012 – 16.05.2012

(49) Salvador E., Förster CY., “Correlating RS1 (RSC1A1) and Na+-D-glucose co-transporter SGLT1 (SLC5A1) expressions in in vitro models of the blood brain barrier (BBB)”, 14. Bad Herrenalber Transporter-Tage 2012, Bad Herrenalb, Germany, 14.05.2012 – 16.05.2012

(48) Shityakov, S., Förster CY., “Multidrug resistance protein P-gp interaction with nanoparticles (fillerenes and carbon nanotube) to assess drug delivery to the CNS: a molecular docking study”, 14. Bad Herrenalber Transporter-Tage 2012, Bad Herrenalb, Germany, 14.05.2012 – 16.05.2012

(47) Salvador E., Neuhaus W., Wais S., Thal S. and Förster CY., “Sodium-dependent glucose transporters expression in the blood brain barrier after injury and its contribution to edema formation”, International Symposium of the SFB 581 Molecular Models for diseases of the nervous system, Würzburg, Germany, 19.04.2012 – 21.04.2012

(46) Kleinschnitz C, Blecharz K, Kahles T, Schwarz T, Kraft P, Göbel K, Meuth SG, Burek M, Thal S, Scheffer D, Thum T, Stoll G, and Förster CY, “Novel steroid-based strategy to restore blood brain barrier integrity and combat tissue edema after ischemic brain injury", 7th International Update on Interdisciplinary Neursoscience - EURO-NEURO Meeting, Vienna, Austria, 17.02.2012 – 18.02.2012

(45) Sebastiani A, Yang D, Luh C, Koepsell H, Neuhaus W, Werner C, Engelhard K, Förster CY, Thal SC, “Deficiency in Sodium-Dependent Glucose Transporter 1 has no effect on brain edema formation after traumatic brain injury”, 7th International Update on Interdisciplinary Neursoscience - EURO-NEURO Meeting, Vienna, Austria, 17.02.2012 – 18.02.2012

(44) Kleinschnitz C, Blecharz K, Kahles T, Schwarz T, Kraft P, Göbel K, Meuth SG,Burek M, Thal S, Scheffer D, Thum T, Stoll G, and Förster C, “Novel steroid-based strategy to restore blood brain barrier integrity after ischemic brain injury", Joint Meeting of the ESM and GfMVB, Munich, Germany, 13.10.2011 – 16.10.2011

(43) Burek M, Förster C, “Cytokine expression in the mouse brain microvascular endothelial cell line cEND after dexamethasone treatment.,” 27. Arbeitstagung der Anatomischen Gesellschaft, Würzburg, Germany, 28.09.2011 -30.09.2011

(42) Burek M, Blecharz KG, Bauersachs J, Thum T, Tsikas D, Widder J, Roewer N, Förster C, “Restoration of endothelial nitric oxide bioavailability in myocardial endothelial cells treated with dexamethasone.”, 6th European Meeting for Vascular Biology and Medicine, Krakow, Poland, 21.09.2011 – 24.09.2011

(41) Christoph Kleinschnitz, Kinga Blecharz, Timo Kahles, Tobias Schwarz, Peter Kraft, Kerstin Göbel, Sven G. Meuth, Malgorzata Burek, Serge Thal, David Scheffer, Thomas Thum, Guido Stoll, and Carola Förster, “Glucocorticoid signalling and resistance at the blood-brain barrier in central nervous system disorders” 6th  European Meeting for Vascular Biology and Medicine, Krakow, Poland, 21.09.2011 – 24.09.2011

(40) Prinz M, Alptüzün V, Fallarero A, Burek M, Förster C, Holzgrabe U, „Alzheimer’s Disease: New Promising compounds with multiple effects and blood-brain-mobility“, Joint Meeting of the Austrian and German Pharmaceutical Societies, Innsbruck, Austria, 20.09.2011 – 23.09.

(39) Neuhaus W, Burek M, Djuzenova Ch, Koepsell H, Roewer N, Förster C, “NMDA-receptor antagonist MK801 attenuates up-regulation of glucose uptake after oxygen/glucose deprivation in a blood-brain barrier in vitro model”, 9th International Conference on Cerebral Vascular Biology, Leiden, Niederlande, 21.06.2011 – 25.06.2011

(38) Neuhaus W, Burek M, Djuzenova Ch, Koepsell H, Roewer N, Förster C, “NMDA-receptor antagonist MK801 attenuates up-regulation of glucose uptake after oxygen/glucose deprivation in a blood-brain barrier in vitro model”,8th International Symposium on the Biology of Endothelial Cells, Zürich, Schweiz, 15.06.2011 – 18.06.2011

(37) Neuhaus W, Förster C, „Establishment of an alveolar epithelial cell in vitro model based on human cell line H441“13. Bad Herrenalber Transporter-Tage, Bad Herrenalb, 30.05.2011 – 01.06.2011

(36) Burek M, Förster C, “Dexamethasone-Wirkung auf die Expression von Zytokinen in der murinen Hirnendothelzelllinie cEND“, 13. Bad Herrenalber Transporter-Tage, Bad Herrenalb, 30.05.2011 – 01.06.2011

(35) Förster C, “Combination therapy of glucocorticoids and proteasome inhibitors as novel treatment option for acute ischemic stroke”XXVth International Symposium on Cerebral Blood Flow, Metabolism, and Function Brain, Barcelona, Spanien, 25.05.2011 – 28.05.2011

(34) Burek M, Blecharz KG, Foerster C, “Claudin-5 as a novel estrogen target in vascular endothelium.”, 8th Cerebral Vascular Biology, Sendai, Japan, 28.06.2009- 02.07.2009,

(33) Blecharz KG, Burek M, Foerster C, “Dexamethasone induces the expression of metalloproteinase inhibitor TIMP-1 in the murine cerebral vascular endothelial cell line cEND.”, Treffen der Gesellschaft für Studien der Blut-Hirn-Schranke (S.E.I.S.C.), Strasbourg, Frankreich, 24.04.2009 – 25.04.2009

(32) Förster C, “Estrogen-dependent regulation of claudin-5 in endothelial cells lines”, Gordon Research Conference Brain barriers, Tilton, New Hampshire, USA, 21.06.2008 – 27.06.2008

(31) Lecht S, Cohen G, Foerster C, Lelkes PI and Lazarovici P, “Heart endothelium is producing and affected by nerve growth factor – relation to reparative angiogenesis”, in The XXIV Annual Meeting of the Israeli Group for Heart Research, Jerusalem, Israel, 2008

(30) Lecht, s., Förster, C., Krilovetzky, I., Marcinkiewicz P.I., Lelkes, P.I. and Lazarovici,, P., “Differential Expression of bFGF in brain and cardiac capillary endothelial cells.”, 8th world congress for microcirculation, , Milwaukee, WI, USA, Intl. Proceedings P 33-36, 15.08.2007 – 19.08.2007

(29) Burek M and Förster C, “Identification of estrogen receptor target genes in the blood brain barrier endothelium.”, 24. Arbeitstagung der Anatomischen Gesellschaft, Würzburg, 2007

(28) Förster C and C. Silwedel , “Differential susceptibility of cerebral and cerebellar endothelial cell lines to blood-brain barrier breakdown in response to inflammatory stimuli.”, IBBS Symposium, Portland, OR, USA, März 2007

(27) Förster C, C. Silwedel, N. Golenhofen, D. Drenckhahn., “Glukocortikoid-Signaltransduktion als molekularer Mechanismus der Permeabilitätsregulation in Endothelzellen der Blut-Hirn-Schranke.“, Arbeitstagung der Anatomischen Gesellschaft, Würzburg, 29.09.2004 – 01.10.2004.

(26) Förster C, C. Silwedel, N. Golenhofen, D. Drenckhahn., „Investigation of blood-brain barrier qualities in immortalised microcapillary endothelial cells generated from mouse brain.”, 7th intl. Symposium Signal Transduction in the Blood-Brain Barriers, Universität Potsdam, 16.09.2004 - 19.09.2004

(25) Förster C, “Developing a Scientific Carreer. Marie Curie Fellowships European Scientific Workshop.”, Participation invited as Rapporteur for EC Marie Curie Annals, Donostia-San Sebastián, Spanien, 28.11.2002 – 30.11.2002

(24) Förster C, G-J. Shim et al., and Jan-Åke Gustafsson, “Involvement of estrogen receptor beta in tissue differentiation”, Keynote lecture, Nuclear receptors, Huddinge, Schweden, 25.08.2002 – 28.08.2002

(23) Förster C, „Brain endothelium and pathologies”, Conference Philippe Laudat, Aix-Les-Bains, Frankreich, 19.10.2002 – 23.10.2002

(22) Förster C and J.-Å. Gustafsson, “Increased apoptosis and reduced  N-cadherin and Cx43 expression in ERbeta mouse cardiac myocytes.”, XIVth World Congress of Cardiology, Sydney, Australien, 05.05.2002 – 09.05.2002

(21) Förster C, G. Cheng, S. Saji, M. Warner and J.-A. Gustafsson, “ER beta involvement in cell cycle regulation and apoptosis in the mammary gland.”, State-of-the-Art conference on cancer, Cancerfonden, Stockholm, Schweden, 26.08.2001 – 28.08.2001

(20) Förster C, S. Saji, M. Warner and J.-A. Gustafsson, “Cell cycle dysregulation in estrogen receptor beta knock-out mice.”, Gordon conference on mammary gland biology, Bristol, RI, USA, 03.06.2001 – 08.06.2001

(19) Förster C and P.M. Kane, “Ca2+  homeostasis as a constitutive V-ATPase function in Saccharomyces cerevisiae.”, European  Bioenergetics conference EBEC, , Brighton, Sussex, UK, 09.09.2000 - 14.09.2000

(18) Förster C and P.M. Kane, “The V-ATPase plays a critical role in regulation of cytosolic Ca2+ concentration.”, Northeast Regional Yeast Meeting, Syracuse, NY, USA, 13.07.2000 – 14.07.2000

(17) Förster C, M.A. Santos, S. Ruffert, R. Krämer and J.L. Revuelta “Redirection of metabolite fluxes in Ashbya gossypii vma1 mutants.”, Fifth European Conference on Fungal Genetics FGSC, Arcachon, Frankreich, 25.03.2000 – 29.03.2000

(16) Förster C, “Roles of the vacuolar H+-ATPase in solute transport and Ca2+ homeostasis.”, Karolinska Institutet, Dept. Medical Nutrition, Stockholm, Schweden, 18.02.2000

(15) Förster C, “Physiological consequence of loss of ATPase activity in the Saccharomycetaceae A. gossypii and Saccharomyces cerevisiae - a comparative study filamentous fungus vs. budding yeast.”, State University of NY, Syracuse, NY, USA, Oktober 1999

(14) Förster C, “Biochemical and molecular biological characterisation of riboflavin transport in A. gossypii”, Dept. Biochem. and Molec. Biol., SUNY Health Science Center at Syracuse, Syracuse, NY, USA, Juni 1999

(13) R.Hecker, Förster C und R. Krämer, “Identification of vacuolar carrier proteins in S. cerevisiae und A. gossypii”, Jahrestagung Graduiertenkolleg Molekulare Physiologie, Max-Planck-Institut fuer Züchtungsforschung, Köln, 13.05.1999

(12) Förster C, „Biochemische und molekularbiologische Charakterisierung des Riboflavintransports in A. gossypii.“, Young researchers award presentation, Frühjahrstagung der VAAM, Göttingen, 09.03.1999

(11) Förster C, Reinhard Krämer and J.L. Revuelta, „Redirection of riboflavin fluxes in the biotechnologically important fungus A. gossypii by disruption of the VMA1-gene“, Frühjahrstagung der VAAM, Göttingen, 07.03.1999 – 10.03.1999

(10) Förster C and R. Krämer, „Strategies to redirect vacuolar riboflavin fluxes in the filamentous fungus A. gossypii., BASF AG, Division „Mikrobielle Synthesen Ludwigshafen, Oktober 1998

(9) Maeting I, Förster C, Sahm H and Stahmann K-P, „Enzymkompartimentierung in Ashbya“, VAAM Workshop Mykologie, Jena, 1998

(8) Förster C, Thomas Hermann and Reinhard Krämer, „Compartmentation of amino acid pools in Ashbya gossypii is dependent on the action of the vacuolar ATPase“, Frühjahrstagung der VAAM, Frankfurt/ M, 22.03.1998 – 25.03.1999

(7) Förster C, Ma. A. Santos, J.L. Revuelta and R. Krämer:, „Cloning, sequencing and disruption of the VMA1 gene of Ashbya gossypii“, Industry cooperation meeting, Institut für Biotechnologie, Forschungszentrum Jülich, März 1998

(6) Förster C and R. Krämer „Vacuolar compartmentation of riboflavin in Ashbya gossypii“, Departamento de Microbiologia y Genetica, Universidad de Salamanca, Spanien, Oktober 1997

(5) Förster C, Stephan Marienfeld, Ralf Wilhelm and Reinhard Krämer, „Monitoring riboflavin fluxes across the vacuolar membrane of the filamentous fungus Ashbya gossypii by selective permeabilization of the plasma membrane“, Forum for applied biotechnology, Gent, Belgien, September 1997

(4) Förster C and Reinhard Krämer, „Evidence for carrier-mediated transport of riboflavin in Ashbya gossypii“, Frühjahrstagung der VAAM, Hamburg, 16.03.1997 – 19.03.1997

(3) Förster C and R. Krämer, „Experimental acess to vacuoles in the filamentous fungus A. gossypii“ BASF AG, Division „Mikrobielle Synthesen“, Ludwigshafen, April 1997

(2) Förster C, Camille Lambert, Volker Wendisch and Reinhard Krämer, „Osmoregulation in the riboflavin overproducer Ashbya gossypii“, VAAM-Workshop Regulation in fungi, 21.11.1996 - 22.11.1996

(1) Förster C and R. Krämer, ”Adaptation ofl the filamentous fungus A. gossypii to hyperosmotic stress - strategies to overcome the effects of low water activity in the industrial fed-batch fermentation process”, Forschungszentrum Jülich, Jülich, Germany, Oktober 1996

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