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Häufig jedoch kann eine infarktgrößen-reduzierende Therapiestrategie erst dann angewandt werden, wenn sich der betroffene Patient zur Behandlung eines bereits eingetretenen Herzinfarkts oder Schlaganfalls vorstellt.

Volatile Anästhetika reduzieren selbst dann die Infarktgröße, wenn sie erst ab dem Moment der Gefäßwiedereröffnung appliziert werden (sog. Postkonditionierung).

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Originalarbeiten

Jazbutyte V, Stumpner J, Redel A, Lorenzen JM, Roewer N, Thum T, Kehl F: Aromatase Inhibition Attenuates Desflurane-Induced Preconditioning against Acute Myocardial Infarction in Male Mouse Heart In Vivo. PLoS One 2012, Epub ahead of print.

Redel A, Stumpner J, Smul TM, Lange M, Jazbutyte V, Ridyard DG, Roewer N, Kehl F:  Endothelial Nitric Oxide Synthase Mediates the First and Inducible Nitric Oxide Synthase Mediates the Second Window of Desflurane-Induced Preconditioning. Journal of Cardiothoracic and Vascular Anesthesia 2012, Epub ahead of print.

Stumpner J, Redel A, Hilz T, Tischer-Zeitz T, Smul TM, Eisenbarth H, Schick MA, Kehl F, Roewer N, Lange M: Desflurane-induced and ischaemic postconditioning against myocardial infarction are mediated by Pim-1 kinase. Acta Anaesthesiologica Scandinavica 2012, 56:904-13.

Stumpner J, Lange M, Beck A, Smul T, Lotz C, Kehl F, Roewer N, Redel A: Desflurane-induced postconditioning against myocardial infarction is mediated by calcium-activated potassium channels: role of the mitochondrial permeability transition pore. British Journal of Anaesthesia 2012, 108:594- 601.

Lotz C, Lazariotto M, Redel A, Smul TM, Stumpner J, Blomeyer C, Tischer-Zeitz T, Schmidt J, Pociej J, Roewer N, Kehl F, Lange M. Activation of peroxisome-proliferator-activated receptors {alpha} and {gamma} mediates remote ischemic preconditioning against myocardial infarction in vivo.

Exp Biol Med (Maywood). 2011 Jan 1;236(1):113-22. Epub 2010 Dec 16.

Lotz C, Lange M, Redel A, Stumpner J, Schmidt J, Tischer-Zeitz T, Roewer N, Kehl F. Peroxisome-Proliferator-Activated Receptor {gamma} Mediates the Second Window of Anesthetic-Induced Preconditioning. Exp Physiol. 2010 Dec 1.

Smul TM, Stumpner J, Blomeyer C, Lotz C, Redel A, Lange M, Roewer N, Kehl F. Propofol Inhibits Desflurane-Induced Preconditioning in Rabbits. J Cardiothorac Vasc Anesth. 2010 Oct 12.

Lotz C, Fisslthaler B, Redel A, Smul TM, Stumpner J, Pociej J, Roewer N, Fleming I, Kehl F, Lange M. Activation of Adenosine-Monophosphate-Activated Protein Kinase Abolishes Desflurane-Induced Preconditioning Against Myocardial Infarction In Vivo. J Cardiothorac Vasc Anesth. 2010 Apr 22.

Stumpner J, Redel A, Kellermann A, Lotz CA, Blomeyer CA, Smul TM, Kehl F, Roewer N, Lange M.Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction. Anesthesiology. 2009 Dec;111(6):1257-64.

Redel A, Stumpner J, Tischer-Zeitz T, Lange M, Smul TM, Lotz C, Roewer N, Kehl F.Comparison of isoflurane-, sevoflurane-, and desflurane-induced pre- and postconditioning against myocardial infarction in mice in vivo. Exp Biol Med (Maywood). 2009 Oct;234(10): 1186-91.

Smul TM, Redel A, Stumpner J, Lange M, Lotz C, Roewer N, Kehl F. Time Course of Desflurane-induced Preconditioning in Rabbits. J Cardiothorac Vasc Anesth. 2009 May 19. [Epub ahead of print]

Lange M, Redel A, Lotz C, Smul TM, Blomeyer C, Frank A, Stumpner J, Roewer N, Kehl F: Desflurane-induced postconditioning is mediated by beta-adrenergic signaling: role of beta1- and beta2-adrenergic receptors, protein kinase A, and calcium/calmodulin-dependent protein kinase II. Anesthesiology. 2009;110:516-28.

Lange M, Redel A, Smul TM, Lotz CA, Nefzger T, Stumpner J, Blomeyer C, Gao F, Roewer N, Kehl F: Desflurane-induced preconditioning has a threshold that is lowered by repetitive application and is mediated by beta2 adrenergic receptors. Journal of Cardiothoracic and Vascular Anesthesia, 2009;23:607-13

Smul TM, Lange M, Redel A, Stumpner J, Lotz CA, Roewer N, Kehl F. Desflurane-Induced Cardioprotection Against Ischemia-Reperfusion Injury Depends On Timing. J Cardiothorac Vasc Anesth. 2009;23:600-606

Lange M, Smul TM, Redel A, Lotz C, Jazbutyte V, Schnupp V, Roewer N, Kehl F: Differential role of calcium/calmodulin-dependent protein kinase II in desflurane-induced preconditioning and cardioprotection by metoprolol: metoprolol blocks desflurane-induced preconditioning. Anesthesiology. 2008;109:72-80.

Redel A, Lange M, Jazbutyte V, Lotz C, Smul TM, Roewer N, Kehl F: Activation of Mitochondrial Large-Conductance Calcium-Activated K+ Channels via Protein Kinase A Mediates Desflurane-Induced Preconditioning. Anesth Analg 2008; 106: 384-391

Redel A, Jazbutyte V, Smul TM, Lange M, Eckle T, Eltzschig H, Roewer N, Kehl F: Impact of ischemia and reperfusion times on myocardial infarct size in mice in vivo. Exp Biol Med (Maywood) 2008; 233: 84-93

Smul TM, Lange M, Redel A, Burkhard N, Roewer N, Kehl F: Desflurane-induced preconditioning against myocardial infarction is mediated by nitric oxide. Anesthesiology 2006; 105: 719-25

Lange M, Smul TM, Blomeyer CA, Redel A, Klotz KN, Roewer N, Kehl F: Role of the beta1-adrenergic pathway in anesthetic and ischemic preconditioning against myocardial infarction in the rabbit heart in vivo. Anesthesiology 2006; 105: 503-10

Eckle T, Grenz A, Kohler D, Redel A, Falk M, Rolauffs B, Osswald H, Kehl F and Eltzschig HK (2006). Systematic evaluation of a novel model for cardiac ischemic preconditioning in mice. American Journal of Physiology-Heart and Circulatory Physiology: 291, H2533-H2540

Payne RS, Akca O, Roewer N, Schurr A and Kehl F (2005). Sevoflurane-induced preconditioning protects against cerebral ischemic neuronal damage in rats. Brain Research: 1034, 147-152

Kehl F, Smul T, Lange M, Redel A and Roewer N (2005). Organ protection by volatile anaesthetics. Anasthesiologie & Intensivmedizin: 46, 491-505

Yu M, Cambj-Sapunar L, Kehl F, Maier KG, Takeuchi K, Miyata N, Ishimoto T, Reddy LM, Falck JR, Gebremedhin D, Harder DR and Roman RJ (2004). Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. European Journal of Pharmacology: 486, 297-306

Kehl F, Payne RS, Roewer N and Schurr A (2004). Sevoflurane-induced preconditioning of rat brain in vitro and the role of K-ATP channels. Brain Research: 1021, 76-81

Kehl F, Ladisa JF, Hettrick DA, Kersten JR, Warltier DC and Pagel PS (2003). Influence of isoflurane on left atrial function in dogs with pacing-induced cardiomyopathy: Evaluation with pressure-volume relationships. Journal of Cardiothoracic and Vascular Anesthesia: 17, 709-714

Kehl F, Krolikowski JG, Weihrauch D, Pagel PS, Warltier DC and Kersten JR (2003). N-acetylcysteine restores isoflurane-induced preconditioning against myocardial infarction during hyperglycemia. Anesthesiology: 98, 1384-1390

Kehl F, Krolikowski JG, LaDisa JF, Kersten JR, Warltier DC and Pagel PS (2003). Adenosine type 1 (A(1)) receptors mediate protection infarction produced by chronic, intermittent ingestion against myocardial of ethanol in dogs. International Journal of Cardiology: 88, 175-182

Hettrick DA, Mittelstadt JR, Kehl F, Kress TT, Tessmer JP, Krolikowski JG, Kersten JR, Warltier DC and Pagel PS (2003). Atrial pacing lead location alters the hemodynamic effects of atrial-ventricular delay in dogs with pacing induced cardiomyopathy. Pace-Pacing and Clinical Electrophysiology: 26, 853-861

Tanaka K, Weihrauch D, Kehl F, Ludwig LM, LaDisa JF, Kersten JR, Pagel PS and Warltier DC (2002). Mechanism of preconditioning by isoflurane in rabbits: A direct role for reactive oxygen species. Anesthesiology: 97, 1485-1490

Tanaka K, Kehl F, Gu WD, Krolikowski JG, Pagel PS, Warltier DC and Kersten JR (2002). Isoflurane-induced preconditioning is attenuated by diabetes. American Journal of Physiology-Heart and Circulatory Physiology: 282, H2018-H2023

Kehl F, Shen H, Moreno C, Farber NE, Roman RJ, Kampine JP and Hudetz AG (2002). Isoflurane-induced cerebral hyperemia is partially mediated by nitric oxide and epoxyeicosatrienoic acids in mice in vivo. Anesthesiology: 97, 1528-1533

Kehl F, Krolikowski JG, Tessmer JP, Pagel PS, Warltier DC and Kersten JR (2002). Increases in coronary collateral blood flow produced by sevoflurane are mediated by calcium-activated potassium (BKCa) channels in vivo. Anesthesiology: 97, 725-731

Kehl F, Krolikowski JG, Mraovic B, Pagel PS, Warltier DC and Kersten JR (2002). Hyperglycemia prevents isoflurane-induced preconditioning against myocardial infarction. Anesthesiology: 96, 183-188

Kehl F, Krolikowski JG, Mraovic B, Pagel PS, Warltier DC and Kersten JR (2002). Is isoflurane-induced preconditioning dose related? Anesthesiology: 96, 675-680

Kehl F, Krolikowski JG, Mraovic B, Pagel PS, Warltier DC and Kersten JR (2002). Isoflurane-induced preconditioning is dose-dependent. Faseb Journal: 16, A489-A489

Kehl F, Kress TT, Mraovic B, Hettrick DA, Kersten JR, Warltier DC and Pagel PS (2002). Propofol alters left atrial function evaluated with pressure-volume relations in vivo. Anesthesia and Analgesia: 94, 1421-1426

Kehl F, Cambj-Sapunar L, Maier KG, Miyata N, Kametani S, Okamoto H, Hudetz AG, Schulte ML, Zagorac D, Harder DR and Roman RJ (2002). 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. American Journal of Physiology-Heart and Circulatory Physiology: 282, H1556-H1565

Gare M, Mraovic B, Kehl F, Kersten JR, Warltier DC and Pagel PS (2002). Reactive oxygen species contribute to contractile dysfunction following rapid ventricular pacing in dogs. International Journal of Cardiology: 83, 125-131

Briefe an den Herausgeber

Lange M, Roewer N, Kehl F. Anesthetic preconditioning as the alternative to ischemic preconditioning. Journal of Thoracic and Cardiovascular Surgery 2006;131(1):252-3 (3,263)

Lange M, Roewer N, Kehl F. Beta-blockers and anesthetic preconditioning: Friend or foe? Canadian Journal of Anaesthesia 2007;54:320-1

Lange M, Redel A, Roewer N, Kehl F. Beta-Blockade Abolishes Anesthetic Preconditioning: Impact on Clinical Applicability. Anesthesiology 2007;106(5):1061-2

Lange M, Riess M. Esmolol may abolish volatile anesthetic-induced postconditioning by scavenging reactive oxygen species. Anesthesiology 2009;111:925

Übersichtsarbeiten

Kehl F, Lange M, Smul T, Redel A, Roewer N. Anästhetika-induzierte Präkonditionierung als Prinzip der perioperativen Risikoreduktion. Anästhesie CME online, Ausgabe 1-2006

Kehl F, Smul T, Lange M, Redel A, Roewer N. Organprotektion durch volatile Anästhetika. Anästh Intensivmed 2005;46: 491-506

Buchbeiträge

Stumpner J, Lange M: Präkonditionierung durch volatile Anästhetika: Fakt oder Fiktion? In:   Eckart/Jäger/Möllhoff: Kompendium Anästhesiologie, 29. Ergänzungslieferung, 2012.

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